Enclomiphene
Important Safety Information
Off-label use: Enclomiphene is not FDA-approved, but clinical studies have evaluated its use for male hypogonadism and fertility support. Patients should understand its regulatory status and ensure it is obtained from a reliable source.
Monitoring: Ongoing monitoring is recommended, including testosterone and estradiol levels, semen analysis, and evaluation for any contraindications (such as liver disease or pituitary abnormalities).
Indications/Use
Investigational use for secondary (hypogonadotropic) hypogonadism in men who wish to maintain or improve fertility.
Functions as an estrogen receptor blocker in the hypothalamus, increasing GnRH, LH, and FSH production—supporting natural testosterone and sperm production.
Contraindications
Allergy or hypersensitivity to enclomiphene or related medications (e.g., clomiphene).
Liver disease or impaired liver function.
Known or suspected pituitary or hypothalamic tumors, as the medication stimulates these pathways.
Use caution in individuals with elevated prolactin; diagnostic imaging (such as MRI) is often recommended prior to starting therapy.
Side Effects
Common: Hot flashes or night sweats (due to aromatization), mood changes, headaches, and occasional visual symptoms (e.g., blurred vision).
Gastrointestinal: Nausea, abdominal discomfort.
Reproductive: Testicular sensitivity from increased activity, erection changes. Note: Enclomiphene can increase the likelihood of multiple pregnancies in women, though this is not relevant for male patients.
Thromboembolic risk: Rare but possible because of its interaction with estrogen pathways.
Long-term use: Limited long-term data; extended therapy should be approached with caution.
Other: Sleep disturbances, swelling, and nipple sensitivity may also occur.
