TRT Treatment Options: Injectable, Cream, and Enclomiphene

PrescribedRX offers three options: injectable testosterone cypionate, a compounded testosterone cream, and enclomiphene (a compounded tablet that helps your body make its own testosterone). Compounded medications are not FDA approved. Your clinician will recommend the best option based on your lifestyle, preferences, and clinical profile.

Option 1: Injectable Testosterone (Testosterone Cypionate)

This is the most commonly prescribed and most precise form of TRT.

• Starting dose: 75–100 mg per week, divided into two doses
• Administration: Subcutaneous injection using a 25–30 gauge, ½” needle
• Injection sites: Abdomen (2+ inches from the navel), outer thigh, or upper buttock
• Important: Rotate injection sites every time to prevent tissue damage and scarring

Injectable testosterone offers the most consistent hormone levels and is easiest to adjust based on lab results.

Option 2: Testosterone Cream (Compounded)

For patients who prefer a needle-free option.

• Format: A compounded testosterone cream, applied once a day
• Dose: Set by your provider based on your hormone panel, and adjusted using your follow-up labs
• Apply to clean, dry skin at the site your provider recommends, and let it absorb fully before covering with clothing

⚠️ Transfer Warning: Testosterone cream can transfer to partners or children through skin contact. Always cover the application site and wash your hands thoroughly after applying. If a child or female partner is exposed, contact a healthcare provider.

Option 3: Enclomiphene (Compounded Tablet)

Enclomiphene is not testosterone. It is a daily tablet that prompts your body to produce more of its own testosterone, rather than replacing it.

• Format: A compounded tablet, taken once a day
• Dose: Set by your provider based on your hormone panel
• Fertility: Because it supports your own production, enclomiphene does not suppress fertility the way testosterone replacement can. It is often considered by men who want to preserve fertility.