In addition to direct testosterone replacement, PrescribedRX offers supplemental and alternative therapies that support hormone health, preserve fertility, and manage estrogen balance.
Enclomiphene #
Enclomiphene stimulates your body to produce its own testosterone naturally by signaling the pituitary gland to increase LH and FSH output. It is an ideal option for men who want to preserve fertility and avoid testicular atrophy.
- Starting dose: 12.5 mg/day
- Dose increase: May be increased to 25 mg/day after 3 months if needed
- Best for: Men who are planning to have children or who prefer stimulating natural production over direct testosterone replacement
HCG (Human Chorionic Gonadotropin) #
HCG mimics Luteinizing Hormone (LH), directly stimulating the testes to produce testosterone. It helps maintain testicular size and preserve fertility — both of which can be affected by traditional TRT.
- Monotherapy (HCG alone): 1,500–2,000 IU subcutaneously, 2–3 times per week
- Combination with TRT: 1,500 IU per week, divided into 2 doses
- Storage: Must be refrigerated. Once mixed, use within 30–60 days.
Anastrozole #
Anastrozole is an aromatase inhibitor prescribed when estrogen (estradiol) levels become elevated as a result of TRT. It is not prescribed routinely — only when clinically indicated.
- Prescribed when: Estradiol > 60 pg/mL, or 40–60 pg/mL with symptoms such as water retention, mood changes, or breast tenderness
- Starting dose: 0.1–0.2 mg twice per week (typically on injection days)
⚠️ Critical Warning: Do NOT use Anastrozole if your estradiol level is normal or low. Over-suppression of estrogen causes joint pain, reduced libido, and bone density loss. Your clinician will only prescribe this when labs confirm elevation.
