Glutathione Injection Dosage: What Studies Used

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Short answer: There is no standard glutathione injection dosage per day or per week for these uses. The human studies cited here used IV glutathione at 600 mg twice a day, 1,200 mg twice a week or 1,400 mg three times a week, and one chemotherapy trial added 600 mg by intramuscular injection on four days; none of them tested subcutaneous injection. Your provider sets the dose.

Below is each study’s dose, route and schedule, what it reported (including results that showed no difference), and what reviews have concluded.

Is there a standard glutathione injection dose?

No. No glutathione injection has prescribing information that sets a dose for wellness or skin uses, so there is no standard dose to quote. What exists is a small set of human studies, each with its own dose, route and schedule.

This page reports the doses used in published human studies. Each study picked its own dose for its own patients, so none of them is a dosing guide.

What doses did human studies use?

Study	Route and dose the study used	Schedule	Who and how long	What was reported
Sechi 1996	IV, 600 mg	Twice daily	9 people with early, untreated Parkinson’s disease; 30 days; open label, no placebo	Authors reported a 42% decline in disability scores
Hauser 2009	IV, 1,400 mg vs placebo	Three times a week	21 people with Parkinson’s disease (11 glutathione, 10 placebo); 4 weeks	No significant differences in symptom scores between groups
Zubair 2016	IV, 1,200 mg with vitamin C vs saline placebo	Twice a week (12 injections)	50 women enrolled, 32 completed; 6 weeks	6 of 16 improved vs 3 on placebo (p = 0.054); authors concluded it was “not very effective” for skin tone lightening
Cascinu 1995	IV, 1.5 g/m2 before chemotherapy, then IM 600 mg	IV weekly with cisplatin; IM on days 2 to 5	50 people with advanced gastric cancer on weekly cisplatin; 15 weeks assessed	Nerve toxicity in 4 of 24 assessable patients vs 16 of 18 on placebo (P = .0001)

Glutathione injection dosage per day

Two cited studies dosed daily. Sechi 1996 gave 600 mg by IV twice a day for 30 days, which is 1,200 mg a day (Sechi et al., 1996). Cascinu 1995 gave 600 mg by intramuscular injection on days 2 to 5 of each weekly chemotherapy cycle, after an IV dose of 1.5 g/m2 on the chemotherapy day (Cascinu et al., 1995). Both studies enrolled people with serious illness (Parkinson’s disease and gastric cancer), not wellness users.

Glutathione injection dosage per week

Two placebo-controlled studies dosed a few times a week. Multiplying each study’s own schedule gives these weekly totals:

• Zubair 2016: 1,200 mg twice a week, or 2,400 mg a week, for 6 weeks (Zubair et al., 2016).
• Hauser 2009: 1,400 mg three times a week, or 4,200 mg a week, for 4 weeks (Hauser et al., 2009).

These totals describe what happened in those trials. They are not a recommended amount, and every study used IV or intramuscular injection, not the subcutaneous route.

What did those studies report?

Hauser 2009 (Parkinson’s disease). In this randomized, double-blind pilot, symptom scores improved by a mean of 2.8 units more in the glutathione group over 4 weeks (P = 0.32) and worsened by 3.5 units more over the next 8 weeks (P = 0.54), neither statistically significant. The authors reported that glutathione “was well tolerated” with no withdrawals for adverse events, and said any effect “remains to be evaluated in a larger study” (Hauser et al., 2009).

Sechi 1996 (Parkinson’s disease). This study had 9 patients and no placebo group. The authors reported a 42% decline in disability that lasted 2 to 4 months after stopping (Sechi et al., 1996). The later placebo-controlled Hauser trial did not find a significant difference.

Zubair 2016 (skin tone). After 12 injections, 37.5% of the glutathione group and 18.7% of the placebo group improved, a difference that did not reach significance (p = 0.054). At six months after treatment, only one patient kept the improvement. The authors reported adverse effects in all subjects; 8 patients had abnormal liver function tests and 1 had anaphylactic shock, and these patients were excluded along with their matched controls (Zubair et al., 2016).

Cascinu 1995 (chemotherapy). In this randomized, double-blind trial, the glutathione group had fewer cases of cisplatin-related nerve toxicity than the placebo group after 15 weeks (4 of 24 vs 16 of 18) (Cascinu et al., 1995). This finding is specific to people receiving cisplatin and was not about general wellness.

What are the benefits of glutathione injections, according to reviews?

The reviews cited here looked at glutathione for skin lightening:

• A 2016 review said that although IV glutathione is popular, “there is no evidence to prove its efficacy” (Sonthalia et al., 2016).
• A 2025 systematic review found only one placebo-controlled IV study and concluded that “IV glutathione is contraindicated due to lack of efficacy and side effects” (Sarkar et al., 2025).
• A 2026 narrative review listed hepatotoxicity, hypersensitivity and possible kidney and hormonal effects as safety concerns and concluded that “current evidence is too limited to justify routine use for cosmetic skin lightening” (Aloraini et al., 2026).

Has any study tested subcutaneous glutathione injections?

We are not aware of a published human trial of subcutaneous (under the skin) glutathione. Every human study cited on this page gave glutathione by IV or intramuscular injection, while the glutathione injection offered through PrescribedRX is subcutaneous. The doses above therefore cannot be carried over to a subcutaneous product.

Glutathione injection offered through PrescribedRX

The glutathione injection offered through PrescribedRX is a compounded subcutaneous injection. Compounded medications are prepared by licensed pharmacies and are not FDA-approved. None of the studies above tested this product or its subcutaneous route, so their results do not apply to it. Prices as displayed on the product page in October 2026:

Product	Form as listed	3 month plan	Monthly plan
Glutathione Injection 200mg/ml 30ml (compounded)	Subcutaneous injection · Provider-dosed	3 month plan $399 · $133/mo · Billed every 3 months. Cancel anytime.	Monthly plan $169 a month

A licensed provider decides whether it is appropriate for you, and your provider sets the dose. A glutathione nasal spray (also compounded) is listed too, and our injection vs nasal spray comparison covers the differences in form. All plans are on the pricing page.

When should you talk to a doctor?

Talk to a licensed provider before using glutathione injections, especially if you have a health condition or take other medicines. The cited sources reported these problems:

• Abnormal liver function tests and one case of anaphylactic shock in an IV glutathione trial (Zubair et al., 2016).
• Hepatotoxicity and hypersensitivity reactions listed as safety concerns in a 2026 review (Aloraini et al., 2026).

In an emergency, call 911. More detail is in our guide to glutathione side effects and the longevity safety information page.

Frequently asked questions

How much glutathione should I inject per day?

No standard dose exists for that, and this page does not give dosing advice. In the cited studies, one gave 600 mg by IV twice a day for 30 days (Sechi 1996) and one gave 600 mg by intramuscular injection on four days of each chemotherapy week (Cascinu 1995). Your provider sets the dose.

How many times a week is glutathione injected in studies?

The two placebo-controlled IV trials cited here used twice a week (1,200 mg, Zubair 2016) and three times a week (1,400 mg, Hauser 2009). Neither found a statistically significant difference from placebo (symptom scores in Hauser 2009, skin tone in Zubair 2016). Your provider sets the schedule.

How long did glutathione injection studies last?

The treatment periods in the cited studies were short: 4 weeks (Hauser 2009), 30 days (Sechi 1996), 6 weeks (Zubair 2016) and up to 15 weeks of assessment alongside chemotherapy (Cascinu 1995). None measured longer-term use.

How do I find out if glutathione injection is appropriate for me?

If you want a licensed provider to review whether glutathione injection is appropriate for you, start with the eligibility check. You can also browse the longevity treatments or see the glutathione injection plan and its price before you start.

Sources

1. Hauser RA, et al. Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson’s disease. Mov Disord. 2009;24(7):979-983. PubMed. Accessed Oct 2026.
2. Sechi G, et al. Reduced intravenous glutathione in the treatment of early Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 1996;20(7):1159-1170. PubMed. Accessed Oct 2026.
3. Zubair S, Hafeez S, Mujtaba G. Efficacy of intravenous glutathione vs. placebo for skin tone lightening. J Pak Assoc Dermatol. 2016;26:177-181. jpad.com.pk. Accessed Oct 2026.
4. Cascinu S, et al. Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial. J Clin Oncol. 1995;13(1):26-32. PubMed. Accessed Oct 2026.
5. Sonthalia S, Daulatabad D, Sarkar R. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol. 2016;82(3):262-272. PubMed. Accessed Oct 2026.
6. Sarkar R, et al. Glutathione as a skin-lightening agent and in melasma: a systematic review. Int J Dermatol. 2025;64(6):992-1004. PubMed. Accessed Oct 2026.
7. Aloraini K, et al. Glutathione for skin lightening via intravenous, oral, and topical routes: a critical narrative review. J Med Life. 2026;19(7):511-523. PubMed. Accessed Oct 2026.

This article is for general information. It is not medical advice and it is not a recommendation for any particular treatment. Whether a treatment is appropriate for you is a decision for a licensed clinician who has reviewed your health history and current medications.