Royal Medical Center vs Defy Medical: TRT Cost, Labs and Care Compared

Disclosure: PrescribedRX sells its own treatments, so we compete with some of the companies covered here, and we may earn affiliate commissions.

Short answer: Royal Medical Center is the simpler, flat-fee choice. Its all-inclusive TRT program is listed at $195 a month and bundles testosterone, a testicular stimulant, an estrogen blocker, labs, physician consults and shipping. Defy Medical is the more flexible, pay-per-service choice. It charges for each consult, lab and medication separately, says its average male TRT patient spends under $175 a month in year one, and offers more delivery methods plus a wider menu of services.

If you want one predictable bill and a standard injection protocol, Royal fits. If you want long consults, a custom protocol and options like creams or pellets, Defy fits. All competitor details below are as listed on each brand’s site in October 2026. Prices change, so confirm with the clinic before you sign up.

Royal Medical Center vs Defy Medical at a glance

Factor	Royal Medical Center	Defy Medical
Pricing model	Flat monthly program fee	Pay per service, no subscription or contract
Listed TRT price	$195/mo all-inclusive; testosterone-only plan listed at $75	Average under $175/mo in year one, around $125/mo after (Defy’s estimate, not a price guarantee)
Labs	“Comprehensive lab work” included in the monthly fee; follow-up labs at 90 days; lab company not named	Billed separately; LabCorp is the listed partner; follow-up labs at 3 months, then every 6 months
Main TRT treatments	Testosterone injections plus clomiphene, enclomiphene or gonadorelin and an estrogen blocker; hCG mentioned in its FAQ	Injections, topical creams and gels, pellets, nasal gel, plus supporting medications
Other services	Women’s HRT, ED, GLP-1 weight loss, peptides such as sermorelin and PT-141, NAD+	Women’s BHRT, thyroid, ED, weight loss, peptides, primary care, hair loss, in-clinic services
Consult model	Consultation and labs first, then ongoing physician follow-up; virtual vs in-office not spelled out	Telemedicine with initial consults of up to one hour; in-office clinic in Tampa, FL
Where it operates	Office in Deerfield Beach, FL; states served not published	“Most states” by telemedicine; full list not published on the pages we reviewed
Who it suits	Men who want one bill and a standard protocol	Men who want a custom protocol and more delivery options

What is Royal Medical Center?

Royal Medical Center is a hormone therapy practice for men and women based in Deerfield Beach, Florida. Its medical lead is Dr. Dagoberto Rodriguez, MD, who the clinic’s About page says has practiced since 1990 and lists with a Florida medical license. Medications are dispensed by Belmar Pharma Solutions, a compounding pharmacy named in the site footer.

How Royal’s TRT program works

According to Royal’s men’s FAQ, care starts with a consultation, lab testing and a health history review. A plan is then built and medication, supplies and instructions are shipped to your home. Follow-up labs happen about 90 days after you start, and physical exams are done yearly or as your physician directs.

The core protocol uses three medications: testosterone injections, a testicular stimulant (clomiphene, enclomiphene or gonadorelin) and an estrogen blocker. The FAQ also says hCG is sometimes prescribed, based on labs and goals. Royal’s site does not say whether consults are done by video, by phone or in the office, and it does not list the states it serves. Its injection guide does note that some states only allow a one-month supply to ship at a time.

Royal Medical Center pricing

Royal’s TRT page lists the men’s program at $195 a month. It says that fee covers all prescribed medications, supplies, comprehensive lab work, physician consultations and monitoring, and shipping. Its programs page also lists:

• Testosterone-only therapy: $75
• Testosterone with anastrozole: $89
• Enclomiphene: $150
• Clomiphene: $150
• Sermorelin: $175

The programs page does not say what billing period those smaller plans cover or whether labs are included in them. A separate hCG price and a separate initial consult fee are not published.

What is Defy Medical?

Defy Medical is a telemedicine practice that has offered TRT online for “more than a decade,” according to its About page. Its care team is led by Medical Director Dr. Justin Saya. Defy says it treats patients by telemedicine in most US states and also runs an in-office clinic in Tampa, Florida. Patients outside the US can book advice-only consults, but Defy does not ship medication overseas.

How Defy’s TRT care works

Defy starts with a lab panel and an initial consult of up to one hour, where a provider reviews your results and builds a plan. Follow-up consults and labs come three months later, then every six months, per its TRT cost FAQ. Its TRT page lists injectable testosterone, topical creams and gels, pellets and nasal gel, plus supporting medications for testicular health, fertility and estrogen. Defy’s intake form also lists hCG-only care, peptide therapy and an “HPTA axis restart” service. We could not confirm on Defy’s site whether it prescribes enclomiphene.

Defy Medical pricing

Defy does not charge a monthly fee. You pay for each consult, lab and medication when you buy it. Defy estimates that its average male TRT patient spends under $175 a month in the first year and around $125 a month after that. That figure includes testosterone, a weekly aromatase inhibitor, labs and consults. Defy calls it an illustrative estimate, not a price guarantee, and says your cost depends on your dose, delivery method and any extra medications. Defy also says third-party financing is available to qualifying patients.

Individual line items, such as the initial consult fee and the price of the TRT lab panel, are not listed on the Defy pages we reviewed. Third-party reviews quote different numbers, so ask Defy directly. Note that some older pages and reviews cite a higher average (under $250 a month). The current FAQ, updated in August 2026, shows the lower figures above.

Royal Medical Center vs Defy Medical: head to head

Which costs less?

On paper, Defy’s average (under $175 a month in year one) is lower than Royal’s $195 flat fee. But the two numbers measure different things. Royal’s $195 is a fixed price that, per its site, includes three medications and labs. Defy’s number is an average for a protocol of testosterone plus an aromatase inhibitor. If you add hCG, another stimulant or extra panels at Defy, your cost goes up. If you need only testosterone, Royal’s smaller plans may cost less, but their terms are not fully published. For a wider look at what drives TRT pricing, see our TRT cost guide.

How do the labs compare?

Both clinics require labs before and during treatment, which matches guidance from the American Urological Association and the Endocrine Society. Both groups advise confirming low testosterone with more than one morning blood test and monitoring markers like hematocrit and PSA during therapy. Royal folds labs into its fee but does not name its lab partner or list what the panel tests. Defy bills labs separately, uses LabCorp, and publishes its lab catalog so you can see the panels. If you want to know exactly what is being tested, Defy is more transparent. To read your own results, see our guide to normal testosterone levels.

What treatment options does each offer?

Royal’s TRT program is built around injections. Its site lists enclomiphene and clomiphene as stand-alone plans too. Defy offers more ways to take testosterone, including creams, pellets and nasal gel. Many of the medications at both clinics are compounded. The FDA notes that compounded drugs are not FDA approved and are not reviewed for safety, effectiveness or quality before they are sold. Royal’s own site says the same. Enclomiphene is not FDA approved in any form; learn more in what is enclomiphene.

How does the care model differ?

Defy leans on long consults and custom protocols, with no contracts. Royal leans on a set protocol at a set price, with follow-up labs at 90 days. Defy publishes more about its process and where it operates. Royal publishes less, so ask how consults happen and whether it serves your state before you pay.

Who should choose Royal Medical Center vs Defy Medical?

• Choose Royal Medical Center if you want one monthly bill, are fine with injections, and want a stimulant and estrogen blocker included by default.
• Choose Defy Medical if you want a custom plan, longer time with a provider, non-injection options, or care for related issues like thyroid or primary care.
• Look at both carefully if you are trying to protect fertility. Ask each clinic how it handles hCG, enclomiphene or clomiphene for your situation.

Before you start anywhere, it helps to understand the risks. Our guide is TRT safe? covers what large studies, such as the TRAVERSE trial, have found about heart safety. For more clinics side by side, see our best online TRT clinics roundup or our Marek Health vs Defy Medical comparison.

How does PrescribedRX compare?

PrescribedRX is a telehealth platform, not a pharmacy. Prescriptions are written by state-licensed clinicians through Telegra MD and filled by licensed partner pharmacies. Here is how it works:

• Treatments: injectable testosterone cypionate, compounded TRT cream or enclomiphene. Compounded drugs are not FDA approved.
• Price: $387 for a 3-month supply, about $129 a month. Orders renew automatically every 10 weeks so the next supply arrives before you run out. Cancel anytime.
• Labs: a $69 hormone panel (total T, LH, hematocrit and PSA) done at a Quest lab near you. It is required before starting, bought again with each 3-month order, and non-refundable.
• Billing: treatment is only charged if a licensed provider prescribes it. Self-pay, no insurance, free priority shipping. Your provider sets the dose.

Because orders renew every 10 weeks and each comes with a panel, a full year costs more than 12 times $129. Our panel is smaller than what Royal or Defy describe, and we do not offer pellets, nasal gel or hCG. Availability varies by state.

Is Defy Medical legit?

Based on what Defy publishes, yes, it is an established medical practice. It has offered telemedicine TRT for more than a decade, names a physician medical director, runs a physical clinic in Tampa, and requires labs and a consult before prescribing. “Legit” does not mean “right for you,” though. Defy’s pay-per-service model makes the total cost harder to predict, and its average cost figure is an estimate, not a quote.

How much does Royal Medical Center cost?

Royal Medical Center lists its all-inclusive men’s TRT program at $195 a month, which its site says covers medications, supplies, labs, physician consults and shipping. A testosterone-only plan is listed at $75 and enclomiphene at $150. Its site does not publish an initial consult fee, a separate hCG price, or which states it serves, so call the clinic to confirm before you enroll.

Ready to check your levels?

Start with the $69 hormone panel at a Quest lab. A licensed provider reviews your results, and you are only charged for treatment if it is prescribed. Take the eligibility quiz or explore our testosterone hub and the TRT guide first.

Sources

• Royal Medical Center: Testosterone Replacement Therapy (accessed Oct 2026)
• Royal Medical Center: All-Inclusive TRT program (accessed Oct 2026)
• Royal Medical Center: All Programs (accessed Oct 2026)
• Royal Medical Center: Men’s FAQs (accessed Oct 2026)
• Royal Medical Center: About (accessed Oct 2026)
• Defy Medical: How much does TRT cost with Defy Medical? (accessed Oct 2026)
• Defy Medical: Online TRT Clinic (accessed Oct 2026)
• Defy Medical: About Us (accessed Oct 2026)
• Defy Medical: Lab Testing (accessed Oct 2026)
• FDA: Compounding and the FDA, Questions and Answers (accessed Oct 2026)
• American Urological Association: Testosterone Deficiency Guideline (accessed Oct 2026)
• Endocrine Society: Testosterone Therapy in Men with Hypogonadism guideline (accessed Oct 2026)
• Lincoff AM et al. Cardiovascular Safety of Testosterone-Replacement Therapy (TRAVERSE). N Engl J Med, 2023. PubMed (accessed Oct 2026)
• Quest Diagnostics: Find a location (accessed Oct 2026)

This article is for general information. It is not medical advice and it is not a recommendation for any particular treatment. Whether a treatment is appropriate for you is a decision for a licensed clinician who has reviewed your health history and current medications.